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Sepsis Management in Resource-limited Settings


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This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings.
More than eighty percent of the worldwide deaths related to sepsis occur in resource-limited settings in low and middle-income countries. Current international sepsis guidelines cannot be implemented without adaptations towards these settings, mainly because of the difference in local resources and a different spectrum of infectious diseases causing sepsis. This prompted members of the Global Intensive Care working group of the European Society of Intensive Care Medicine (ESICM) and the Mahidol-Oxford Tropical Medicine Research Unit (MORU, Bangkok, Thailand) - among which the Editors – to develop with an international group of experts a comprehensive set of recommendations for the management of sepsis in resource-limited settings. Recommendations are based on both current scientific evidence and clinical experience of clinicians working in resource-limited settings. The book includes an overview chapter outlining the current challenges and future directions of sepsis management as well as general recommendations on the structure and organization of intensive care services in resource-limited settings. Specific recommendations on the recognition and management of patients with sepsis and septic shock in these settings are grouped into seven chapters. The book provides evidence-based practical guidance for doctors in low and middle income countries treating patients with sepsis, and highlights areas for further research and discussion. 


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sepsis management in resourcelimited settings it is a great honour to be writing the foreword for the first edition of sepsis management in resourcelimited settings. the publication of this book could not be more timely lives will be saved if the advice and wisdom of the authors of this superb book is translated into everyday clinical care in all settings around the world.


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sepsis management in resourcelimited settings ncbi infection management in patients with sepsis and septic shock in resourcelimited settings c. louise thwaites ganbold lug arjen m. dondorp neill k. j. adhikari jane nakibuuka raep jawa mervyn mer srinivas murthy marcus j. schultz binh nguyen thien and arthur kwizera.


rmendations for sepsis management in resourcelimited specific attention was paid to ntify clinical evnce on sepsis management originatingom resourcelimited settings. based on survey data on the availability of resources to implement the surviving sepsis campaign gulines and american college of critical care medicine pediatric gulines in middle and lowie countries 12 15 scientific evnce was adjusted to resourcelimited settings.


integrating sepsis management rmendations into this sepsis management pathway for resourcelimited settings a subset of the larger severe illness recognition and management algorithms within the imai district clinician manual adheres to these principles and provs an essential first step in improving oues.


hemodynamic assessment and support in sepsis and septic rmendations for hemodynamic assessment and support in sepsis and septic shock in resourcelimited settings are largely lacking. in this chapter we reviewed the literature and provd rmendations regarding hemodynamic assessment and support taking into consration aspects of efficacy and effectiveness availability and feasibility and affordability and safety.

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